We would like to take a closer look at the upcoming results of Merrimack Pharmaceuticals’ (MACK) lead drugs, MM-398 and MM-121. MM-398 MM-398 is a liposomal formulation of irinotecan intended for the treatment of pancreatic cancer (PC). Irinotecan is marketed by Pfizer as Camptosar® and approved for first-line treatment of colon cancer in combination with […]
August 1- EOD
Lots of good earnings and conference calls to go through. It is going to take a couple of days to sort through it all so I will try and focus on a couple of companies a day. 1. There was some discussion yesterday about SGEN and the news that the FDA will not add retreatment […]
July 31- EOD
Well, it was certainly a news filled evening and it will take a couple of days to sort through it all, so today will be a first cut. In general it was an odd day in biotech as there were certainly pockets of outperformance but the sector in general seemed weak despite the strength in […]
IBB – Technical Commentary
iShares Nasdaq Biotechnology (IBB) – Nasdaq The best indicators for our biotech portfolio are the biotechnology indices IBB, NBI, XBI or XLV. After publishing “IBB – Biotechnology Index at All Times High“, we wanted to maintain our focus on the IBB. In today’s video “IBB – Market Activity” Tony noted a large bearish bet or hedge […]
July 30th- EOD
While today seemed to have better trading action, the news was actually less interesting than Monday. There are a couple of notes but nothing quite significant. In fact, the most interesting news was in the commodities space with the Potash oligopoly seemingly about to collapse but hard to spin that into biotech. CEMP reports after […]
July 29- EOD
We finally had a major biotech merger but it was not one that got people excited as volumes and price action in biotech were neutral to negative for most of the day. Despite the lack of enthusiasm this was actually a pretty interesting day from the news front, so I will quickly touch on a […]
BCRX – BioCryst – Entering The HAE Market
BioCryst announced on Monday July 22 the successful completion of a Phase I study on the safety and PK of BCX4161, a candidate for the treatment of Hereditary angioedema (HAE). HAE is a genetic disorder resulting from the loss or dysfunction of complement C1 Inhibitor (C1INH). Among the functions performed by C1INH is regulation of […]
Week’s Option Activity (7/23~7/27)
The following stocks had notable activity in their options during the past week: $XOMA (7/23): 2,000 SEP/OCT 5.0 strike Call Time spreads (stock at $5.08) were bought for 0.35 or $70,000 net debit. The SEP 5.0 strike Calls were sold for 0.60 ($120,000 proceeds) and the SEP 5.0 strike Calls were bought for 0.95 ($190,000 […]
July 26-EOD
It was a relatively quiet day on the news front outside of the hep-C space where there as some news on both VRTX and GILD. Not much happening in the afternoon, so wrapping it up a little early. 1. VRTX announced that the FDA put a clinical hold on their all oral trial using VX-135. […]
July 25- EOD
We had a lot of large cap biotech news in terms of the earnings and I wanted to focus on two of them as both had clean beats but also gave some investors pause: CELG and BIIB. 1. BIIB absolutely blew out BG-12 sales. The sell side consensus was $70M and the buyside whisper was […]
July 24- EOD
The news du jour today was SRPT and I want to focus today’s note entirely on it because there is a lot to talk about. In addition, I want to focus on the bearish aspects to the story as I think the bullish case has been fairly well laid out. I would certainly not interpret […]
July 23- EOD
We still seem to be in a period of low news flow in terms of biotech stocks, which is fine as it gives me a chance to catch up on some longer term stories. In particular, I want to spend some time talking about ONTX as it should start trading Thursday and it is an […]
July 22- EOD
It is more of the same in that the market is a little quiet on news. I expected that there would be something interesting to talk about today but not so much. That being said there are a couple of items that I think might be important to note. 1. There has been a lot […]
Week’s Option Activity (7/15~7/19)
The following stocks had notable activity in their options during the past week: $NEPT (7/16): 16,000 (separated into trades of 6,000 and 10,000) AUG 4.0 strike Calls (stock at $3.71) were sold for 0.20 or total proceeds of $320,000. This trade is most likely a covered Call trade of an existing long stock position. $BCRX […]
STML – Follow up on Stemline
In what is becoming increasingly rare these last few months, Stemline made its public debut this January with a drug on track for late stage studies. The company focuses on cancer stem cells, with the clinical candidates SL-401 and SL-701. Today, we will delve into the former, a drug targeted to the IL-3 receptor. Read […]
July 19- EOD
Really seemed like a quiet summer day to end the week. Not much to talk about but a couple of follow up notes from earlier discussions. 1. To continue from my MYGN notes from yesterday, it was confirmed from LH that they will be in the BRCA market. This just builds on the bear case […]
July 18- EOD
Not a ton of news today, so this will be a little bit of a short update but some company specific news with CELG. Outside of that there was the IPO mania that might very well be peaking. I am not convinced that we are in a complete bubble simply because everyone is calling it […]
July 17- EOD
Well, we finally had a biotech merger but not any of the ones we expected. Outside of the small cap buyout, there was not a lot new today. 1. SPPI bought TLON this morning. What is really odd was that I almost wrote about SPPI yesterday but decided against it. When I was thinking about […]
July 16- EOD
Seemed like a slow news day as the markets pulled back to consolidate some of the recent moves. Biotechs were not immune to the move, although some clearly performed better than others. 1. EPZM has shown incredible strength since the IPO. While I like this company’s technology and would like to own some shares, it […]