March 21 Biotech Update

[This was written Friday but the site was down and I was unable to post it. I am publishing it as it was Friday and will write another column later today for more recent news] Well, it was a manic day with a very nice win followed by the broader morning bloodbath in the sector. […]

Quick Confirmation

I just talked to CNAT and confirmed that they have not seen any lipid abnormalities either at the pre-clinical or clinical stages. In addition, they noted that there is no reason to expect the emricisan mechanism of action to generate any lipid abnormalities. Obviously, this does not completely rule anything out but simply confirms my […]

Catalyst Watch – Vol. 2, Edition 8 (3/18/14)

Below are current tactical and strategic thoughts on approaching FDA and clinical trial catalysts for select names. Estimates, values and views are as of the date published (or are noted), are subject to potential future, pre-catalyst revision and are not intended as investment recommendations. Please read our Disclaimer: (1) Catalyst Watch List – Update: CYTK: […]

March 18 Biotech Update- Cause for Optimism?

This morning was much more encouraging than yesterday with the sector finally seeming to outperform the broader market. Obviously one day does not make a trend and even despite the price action; most of it seemed on fairly light volume so this could still be the pause that refreshes for the next move down. In […]

Corcept – Fourth time a charm?

Corcept Therapeutics (CORT) is currently awaiting topline Phase III data for Korlym(mifepristone) in psychotic depression in the second quarter. Currently, Corcept projects Korlym will do net revenue between $24-$28 million under it’s limited label for endogenous Cushing’s syndrome, a rare condition in which the adrenal glands overproduce cortisol. Below you will find an assessment of […]

Quick Take on GERN Clinical Hold

Geron announced this morning the FDA had placed a clinical hold on its lead drug Imetelstat. While the agency cited only trials in ET, PV, and MM, the company also expects a delay in its key Phase II MF study- originally set to begin mid-year. Shares plunged from $4.40 to as low as $1.39, but […]

Catalyst Watch – Vol. 2, Edition 7 (3/12/14)

Below are current tactical and strategic thoughts on approaching FDA and clinical trial catalysts for select names. Estimates, values and views are as of the date published (or are noted), are subject to potential future, pre-catalyst revision and are not intended as investment recommendations. Please read our Disclaimer: (1) Catalyst Watch List – Update: CYTK: […]

Upcoming events for Merck

Members of Chimera Research Group have successfully been trading Merck for the past few months, especially Joe Gantos(@GantosJ). Merck has been one of the strongest big pharmas over the past few month on the heels of pipeline developments. With a new year, we want to provide a road map for what’s to come in the […]

Upcoming events for Pfizer

Pfizer (PFE) isn’t traditionally on my watchlist as a name to follow, however, this may be an exception. Palbocicib is likely the most exciting pipeline product in development at Pfizer right now. It received Breakthrough Therapy designation from the FDA in April 2013 for the treatment of breast cancer, following very encouraging Phase 2 results […]

March 6 Biotech Update- Oh the Humanity

It is Thursday again and as usual I do not have much time to write anything in depth. In general, the broad market looked good but the sector seemed pretty heavy. I cannot shake the feeling that the sector is starting to turn in that the runs higher seem further apart and the intraday dips […]

Week’s Option Activity (2/20 ~ 3/04)

The following stocks had notable activity in their options during the past week(s): $CYTK (2/20): There were two large trades – one bullish and one bearish. (1) Bullish: 2,900 MAY risk reversals were purchased (stock at $9.85) for net 1.10 or total net cost of $319,000 (2,900 MAY 7.50 Strike Puts were sold for 1.90 […]